Bioactivity

Matrix protein, MMP

Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway.
Zhang C, Li Y, Qian ZJ, Lee SH, Li YX, Kim SK.
Evid Based Complement Alternat Med 2011:140462 (2011).

Dieckol Inhibits 12-O-tetradecanoylphorbol-13-acetate-induced SK-Hep1 Human Hepatoma Cell Motility through Suppression of Matrix Metalloproteinase-9 Activity
Oh SM, Park CG, Kang JH, Kim EJ, Chee HY, Lee BH, Lee KB
J Korean Soc Appl Biol Chem 54(3), 376-381 (2011).

Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava.
Zhang C, Li Y, Shi X, Kim SK.
BMB Rep 43(1):62-8 (2010).

MMT Inhibitory Action of Seanol.
Saeki Y, NishiuraH, Tanaka K.
Fragrance J 37:94-96 (2009).

Inhibitory efects of triphlorethol-A on MMP-1 induced by oxidative stress in human keratinocytes via ERK and AP-1 inhibition.
Kang KA, Zhang R, Piao MJ, Ko DO, Wang ZH, Lee IK, Kim BJ, Shin T, Park JW, Lee NH, Yoo BS, Hyun JW.
J Toxicol Environ Health 71:992-999 (2008).

Elastase and hyaluronidase inhibition activities of phlorotannins isolated from Ecklonia cava.
Bu HJ, Ham YM, Kim JM, Lee SJ, Hyun JW, Lee NH.
Kor J Pharmacogn 37:92-96 (2006).

The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts.
Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK.
Biol Pharm Bull 29:1735-1739 (2006).

Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity.
Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG, Jeon YJ, Kim SK.
Life Sci 79:1436-1443 (2006).

An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava.
Shin HC, Hwang HJ, Kang KJ, Lee BH.
Arch Pharm Res 29:165-171 (2006).

Inhibitory activity of brown algal phlorotannins against hyaluronidase.
ShibataT, Fujimoto K, Nagayamak, Yamaguchi K, Nakamura T.
Int J Food Sci Tech 37:703-709 (2002).